S. P. Gygi

The paper identifies high-impact DUBs and their substrates using Xenopus egg extract and proteomics, revealing substrate characteristics influencing DUB specificity.

The paper demonstrates bidirectional substrate shuttling between the 26S proteasome and Cdc48 ATPase in yeast, showing how this process facilitates protein degradation.

This study shows that deleting specific mitochondrial Complex I subunits, Ndufs4 and Ndufs6, enhances tumor immunogenicity and sensitivity to immune checkpoint blockade in mouse melanoma models.

The paper introduces PISA-REX, a high-throughput proteomics method combining redox, expression, and solubility analysis, and demonstrates its application in studying interferon responses in human monocytes and mice.

This study shows that fission yeast CK1 orthologues Hhp1 and Hhp2 promote DNA double-strand break repair through both homologous recombination and non-homologous end joining by phosphorylating substrates like Arp8.

This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.

This study identifies a novel upstream motif in T. spiralis muscle-stage ESPs that can predict secreted proteins, using proteomic and computational methods.

This study identifies RBM43 as a regulator of PGC1alpha translation, linking adipose inflammation to reduced energy expenditure and mitochondrial function in obesity.

This study identifies UBXN1 as a negative regulator of the UPR that represses translation and maintains ER proteostasis independently of p97.

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

This study examines how proteome conformational stability changes in aging C. elegans due to missense mutations and polyglutamine expansions, revealing age-dependent metastable protein networks.

The paper identifies TOM1L2 as a ciliary trafficking factor that recognizes K63-linked ubiquitin chains to retrieve ubiquitinated GPCRs from cilia.

This study identifies hundreds of novel GALNT1 substrates using proteomics tools, revealing preferences for Thr residues and Pro at positions +3 and +4, and implicating GALNT1 in diverse biological pathways.

The paper shows that APC/C-Cdc20-dependent degradation of Clb4 is required for the anaphase switch in astral microtubule dynamics, crucial for spindle orientation.

This study determines the cryo-EM structure of active-state RXFP1 bound to relaxin-2 and Gs protein, revealing an autoinhibition mechanism.

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

This paper develops solvent shift assays to assess target engagement using quantitative proteomics, showing they can identify compound targets and serve as a reliable alternative to existing methods.

This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.

The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.

This study identifies DPP9 as a repressor of NLRP1 inflammasome activation by sequestering the NLRP1 C-terminus, preventing inflammation during protein turnover.

The paper uses proximity labeling and mass spectrometry to profile ciliary proteome changes during Hedgehog signaling, identifying new proteins involved in ciliary exit and signaling regulation.

This study shows poison frogs rapidly accumulate toxins, altering protein abundance in immune response and small molecule transport across tissues.

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

This study identifies IRS2 as an APC/C substrate, showing it regulates cell cycle protein expression and the spindle assembly checkpoint.

The paper identifies proteomic changes in Ubqln2 mutant mice and finds that TRIM32, PEG10, and CXX1B are linked to UBQLN2 function and degradation.

This study identifies PfPP1 as essential for Plasmodium falciparum egress from host erythrocytes and shows it integrates internal and external signals for this process.

The paper was submitted in error and the authors do not wish it to be cited.

The paper introduces a real-time database search platform, Orbiter, that improves the efficiency and accuracy of multiplexed quantitative proteomics by reducing data acquisition time and increasing protein quantification.

The paper uses time-resolved phosphoproteomics to analyze SHP2's role in EGFR signaling, identifying distinct phosphotyrosine response patterns upon SHP099 treatment.