SMARCB1 loss creates patient-specific MYC topologies that drive malignant rhabdoid tumor growth
N. Q. Liu, I. Paassen, L. Custers, H. Teunissen, D. Ayyildiz, J. He, E. W. Hoving, E. de Wit, J. Drost
This study shows that SMARCB1 loss leads to patient-specific MYC enhancer looping, driving MRT growth through epigenetic reprogramming.
bioRxiv · Nov 21, 2022 · PreprintCancer Biology