L. D. Islas

Cation permeability and pore dynamics in TRPV1 ion channels

This study investigates how ion permeation affects voltage dependence in TRPV1 channels using single-channel recordings.

Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid.

This study uses patch-clamp fluorometry with a fluorescent amino acid to reveal voltage and pH-dependent transitions in the activation pathway of human HV1 channels.

Discovery and characterization of Hv1-type proton channels in reef-building corals.

This study identifies and characterizes Hv1-type proton channels in reef-building corals, revealing their biophysical properties and developing an allosteric gating model.

KV1.2 channels inactivate through a mechanism similar to C-type inactivation

This study investigates slow inactivation in rat KV1.2 channels and finds similarities to C-type inactivation in Shaker channels, with some functional differences due to structural variations.

The contribution of the ankyrin repeat domain of TRPV1 as a thermal module

This paper investigates the role of the ankyrin repeat domain (ARD) in TRPV1 thermal sensitivity using computational and biochemical methods, finding that the ARD undergoes structural changes with temperature that may regulate channel activation.

Irreversible temperature gating in trpv1 sheds light on channel activation

The paper identifies an irreversible inactivation process in TRPV1 channels triggered by thermal stimuli, linked to conformational changes in the membrane proximal domain.

Conformational Dynamics In TRPV1 Channels Reported By An Encoded Coumarin Amino Acid

This study uses a genetically encoded fluorescent amino acid to monitor conformational changes in TRPV1 channels, showing that Y671 fluorescence correlates with channel activation by capsaicin.