Identification of a sensory neuron Cav2.3 inhibitor within a new superfamily of macro-conotoxins
C. M. Hackney, P. Florez Salcedo, E. Mueller, L. D. Kjelgaard, M. Watkins, L. G. Zachariassen, P. S. Tuelung, J. R. McArthur, D. J. Adams, A. S. Kristensen, B. Olivera, R. K. Finol-Urdaneta, H. Safavi, J. P. Morth, L. Ellgaard
The paper identifies a new macro-conotoxin, Mu8.1, which selectively inhibits Cav2.3 calcium channels in sensory neurons, highlighting its potential as a molecular tool for studying neuronal subclasses.
bioRxiv · Jul 4, 2022Biochemistry