Author

L. Filer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Kennedy· 1 shared C. Hinze· 1 shared C. Lloyd· 1 shared C. T. Orozco· 1 shared D. Giovacchini· 1 shared D. Sansom· 1 shared E. A. Waters· 1 shared H.-C. Chen· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

A. Kennedy

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1 paper

Recent·Most cited

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

M. A. Robinson, A. Kennedy, C. T. Orozco, H.-C. Chen, E. A. Waters, D. Giovacchini, K. Yeung, L. Filer, C. Hinze, C. Lloyd, S. Dovedi, D. Sansom

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

bioRxiv · Apr 19, 2024 · PreprintImmunology