H.-C. Chen

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

This paper combines three CD4-induced antibodies with a CD4-mimetic to achieve potent ADCC activity against HIV-1-infected cells.

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

Wounding perception by jasmonate-mediated JAZ condensation in plants

This study reveals that JAZ1 undergoes phase separation in response to wounding, facilitating rapid jasmonate signaling by reducing its interaction with MYC2 and recruiting COI1 for degradation.

A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy

The paper identifies IL-21-expressing CD4+ T cells in an inflammatory neuropathy mouse model and shows their role in neuropathy development through clonal expansion and CXCR6-mediated infiltration.

Pantailocins: Phage-derived Bacteriocins from Pantoea ananatis and Pantoea stewartii subsp. indologenes

The paper identifies and characterizes tailocins from Pantoea ananatis and Pantoea stewartii subsp. indologenes, showing they are derived from Myoviridae phages and exhibit killing activity against phytopathogens.

Remote neuronal activity drives glioma infiltration via Sema4f

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis

The paper identifies clonally expanded CD8+ T cells driven by IL21 in ICI-thyroiditis using scRNA-seq and validates their role in thyroid inflammation.

The dynamic linkage between intact provirus integration sites and the host functional genome property alongside HIV-1 infections associated with antiretroviral therapy

This study identifies enriched immunologic signatures and host biological pathways associated with HIV-1 infections under antiretroviral therapy by analyzing genes targeted by intact proviruses.

LGR5 targeting molecules as therapeutic agents for multiple cancer types

This study develops LGR5-targeting antibodies and therapeutics that effectively kill CRC, HCC, and pre-B ALL cancer cells while sparing normal tissues.

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

The paper shows that small CD4 mimetics expose ADCC epitopes on HIV-1-infected macrophages, making them susceptible to antibody-dependent cellular cytotoxicity.

Characterization of human immunodeficiency virus (HIV-1) envelope glycoprotein variants selected for resistance to a CD4-mimetic compound

This study identifies HIV-1 Env variants resistant to CD4-mimetic compounds and BMS-806 by analyzing mutations that confer resistance and their effects on viral fitness and inhibitor sensitivity.

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.

Inhibition of the IL-17A axis Protects against Immune-related Adverse Events while Supporting Checkpoint Inhibitor Anti-tumor Efficacy

This study shows that inhibiting the IL-17A axis reduces immune-related adverse events in checkpoint inhibitor-treated mice without affecting anti-tumor efficacy.

Glycan-masking spike antigen in NTD and RBD elicits broadly neutralizing antibodies against SARS-CoV-2 variants

This study shows that glycan-masking of SARS-CoV-2 NTD and RBD antigens increases neutralizing antibody titers against multiple variants.

HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC mediated by plasma from infected individuals

This study shows that HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC by reducing the exposure of uncleaved Env to non-neutralizing antibodies.

Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation

This study identifies lineage-specific transcription factors and super-enhancers driving neuroblastoma self-renewal and differentiation using ATRA treatment and CRISPR screening.

A SAC phosphoinositide phosphatase controls rice development via hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate

This study identifies GH1, a SAC phosphatase in rice, which hydrolyzes PI4P and PI(4,5)P2, affecting actin cytoskeleton and cell elongation during plant development.

Altered composition of the γδ T cell pool in lymph nodes during ageing enhances tumour growth

This study shows that ageing alters the composition of γδ T cells in lymph nodes, promoting tumour growth in mice.