Combinatorial mutagenesis of rapidly-evolving residues yields super-restrictor antiviral proteins
R. Colon-Thillet, E. Hsieh, L. Graf, R. N. McLaughlin, J. M. Young, G. Kochs, M. Emerman, H. S. Malik
The paper uses combinatorial mutagenesis to generate super-restrictor antiviral proteins against Thogoto virus, finding variants with enhanced restriction activity compared to wild-type MxA.
bioRxiv · Aug 12, 2019Microbiology