Author

G. Kochs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Assay:flow cytometry· 1 Assay:protein sequence· 1

Frequent Co-Authors

M. Schwemmle· 2 shared S. Weigang· 2 shared V. Thiel· 2 shared A. Binz· 1 shared A. Breithaupt· 1 shared A. Decker· 1 shared A. Hickford Martinez· 1 shared A. Nieters· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

M. Schwemmle

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior protective humoral immune response to SARS-CoV-2

A. Taddeo, I. Berenguer Veiga, C. Devisme, R. Boss, P. Plattet, S. Weigang, G. Kochs, V. Thiel, C. Benarafa, G. Zimmer

This study shows that VSV-vectored spike protein vaccines induce protective immunity when trans-complemented with VSV glycoprotein, but do not achieve sterilizing immunity against SARS-CoV-2.

bioRxiv · Jun 14, 2022 · PreprintImmunology

Impaired immune response drives age-dependent severity of COVID-19

J. Beer, S. Crotta, A. Breithaupt, A. Ohnemus, J. Becker, B. Sachs, L. Kern, M. Llorian, N. Ebert, F. Labroussaa, T. T. N. Tran, B. S. Trueeb, J. Jores, V. Thiel, M. Beer, , D. Schnepf

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

bioRxiv · Apr 21, 2022Immunology

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

B. Sodeik, M. C. Serrero, V. Girault, S. Weigang, T. M. Greco, A. Ramos Nascimento, F. Anderson, A. Piras, A. Hickford Martinez, J. Hertzog, A. Binz, A. Pohlmann, U. Prank, J. Rehwinkel, R. Bauerfeind, , G. Kochs

This study identifies MxB as an interferon-inducible GTPase that disassembles herpesvirus capsids, promoting genome release and enhancing innate immune responses.

bioRxiv · Jan 25, 2022Microbiology

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

I. Schulien, J. Kemming, V. Oberhardt, K. Wild, L. M. Seidel, S. Killmer, Sagar, F. Daul, M. Salvat Lago, A. Decker, H. Luxenburger, B. Binder, D. Bettinger, O. Sogukpinar, S. Rieg, , C. Neumann-Haefelin

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

bioRxiv · Aug 13, 2020 · PreprintImmunology

ADA2 is a lysosomal DNase regulating the type-I interferon response

O. K. Greiner-Tollersrud, M. Krausz, E. Bartok, V. Boehler, H. Ebersbach, S. Baash, D. Guerini, G. Hartmann, K. Huebscher, G. Kochs, M. Marchant, A. Polyzou, J. Schepp, M. Seidl, C. R. Smulski, , M. Proietti

The paper identifies ADA2 as a lysosomal DNase that regulates the type-I interferon response by degrading cGAS/Sting-activating ligands in DADA2 patients.

bioRxiv · Jun 21, 2020 · PreprintImmunology

Combinatorial mutagenesis of rapidly-evolving residues yields super-restrictor antiviral proteins

R. Colon-Thillet, E. Hsieh, L. Graf, R. N. McLaughlin, J. M. Young, G. Kochs, M. Emerman, H. S. Malik

The paper uses combinatorial mutagenesis to generate super-restrictor antiviral proteins against Thogoto virus, finding variants with enhanced restriction activity compared to wild-type MxA.

bioRxiv · Aug 12, 2019Microbiology