L. Hinderling

GTPase activating protein DLC1 spatio-temporally regulates Rho signaling

This study shows DLC1 regulates Rho activity levels globally and amplifies local Rho activity at focal adhesions under mechanical stress.

Automatic detection of spatio-temporal signalling patterns in cell collectives

The paper introduces ARCOS, a computational method to detect and quantify spatio-temporal signalling patterns in cell collectives, and demonstrates its application in identifying ERK activity waves in MCF10A cells.