Author

O. Pertz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 6 Organism:human· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Dobrzynski· 5 shared P. A. Gagliardi· 5 shared M.-A. Jacques· 4 shared A. R. Cohen· 3 shared C. Dessauges· 3 shared P. Ender· 3 shared D. Riveline· 2 shared J. van Unen· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersCell Biology

M. Dobrzynski

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Author profile →

9 papers

Recent·Most cited

Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries.

S. Lo Vecchio, O. Pertz, M. Szopos, L. Navoret, D. Riveline

This study shows that coherent cell motion in epithelia arises from competition between cell polarity alignments and active acto-myosin cables at boundaries.

Nature Physics · Jan 8, 2024Peer-reviewedBiophysics

GTPase activating protein DLC1 spatio-temporally regulates Rho signaling

L. Hinderling, M. Heydasch, G. Rochat, L. Dubied, J. van Unen, M. Dobrzynski, O. Pertz

This study shows DLC1 regulates Rho activity levels globally and amplifies local Rho activity at focal adhesions under mechanical stress.

bioRxiv · Jun 19, 2023Cell Biology

Polarity-driven three-dimensional spontaneous rotation of a cell doublet

L. Lu, T. Guyomar, Q. Vagne, R. Berthoz, A. Torres-Sanchez, M. Lieb, C. Martin-Lemaitre, J. van Unen, A. Honigmann, O. Pertz, G. Salbreux, D. Riveline

This study investigates how myosin polarity drives spontaneous 3D rotation in cell doublets embedded in an extracellular matrix.

bioRxiv · Dec 21, 2022Biophysics

Automatic detection of spatio-temporal signalling patterns in cell collectives

P. A. Gagliardi, B. Grädel, M.-A. Jacques, L. Hinderling, P. Ender, A. R. Cohen, G. Kastberger, O. Pertz, M. Dobrzynski

The paper introduces ARCOS, a computational method to detect and quantify spatio-temporal signalling patterns in cell collectives, and demonstrates its application in identifying ERK activity waves in MCF10A cells.

bioRxiv · Jul 12, 2022Cell Biology

LITOS - a versatile LED illumination tool for optogenetic stimulation

T. C. Hoehener, A. Landolt, C. Dessauges, P. A. Gagliardi, O. Pertz

LITOS provides a flexible, affordable, and user-friendly LED illumination system for optogenetic experiments, enabling precise and uniform light stimulation across various formats.

bioRxiv · Mar 2, 2022Cell Biology

Spatio-temporal Control of ERK Pulse Frequency Coordinates Fate Decisions during Mammary Acinar Morphogenesis

P. Ender, P. A. Gagliardi, M. Dobrzynski, A. Frismantiene, C. Dessauges, T. Höhener, M.-A. Jacques, A. R. Cohen, O. Pertz

The paper shows that ERK pulse frequency controls cell fate during mammary acinar morphogenesis, with high frequency promoting survival and low frequency inducing apoptosis.

bioRxiv · Nov 20, 2020Cell Biology

CODEX, a neural network approach to explore signaling dynamics landscapes

M.-A. Jacques, M. Dobrzynski, P. A. Gagliardi, R. Sznitman, O. Pertz

The paper introduces CODEX, a neural network method to analyze time-series signaling data and identify dynamic motifs in single-cell trajectories.

bioRxiv · Aug 5, 2020Cell Biology

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

P. A. Gagliardi, M. Dobrzynski, M.-A. Jacques, C. Dessauges, P. Ender, Y. Blum, R. M. Hughes, A. R. Cohen, O. Pertz

The paper shows ERK/Akt activity waves from apoptotic cells protect neighboring cells and maintain epithelial homeostasis through EGFR and MMP signaling.

bioRxiv · Jun 11, 2020Cell Biology

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

P. M. Mueller, J. Rademacher, R. D. Bagshaw, K. M. Alp, G. Giudice, L. E. Heinrich, C. Barth, R. L. Eccles, M. Sanchez-Castro, L. Brandenburg, G. Mbamalu, M. Tucholska, L. Spatt, C. Wortmann, M. T. Czajkowski, , O. Rocks

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.

bioRxiv · Aug 29, 2018Cell Biology