BiophysicsbioRxiv
Minute-timescale simulations of G Protein Coupled Receptor A2A activation mechanism reveal a receptor pseudo-active state
V. M. D'Amore, P. Conflitti, L. Marinelli, V. Limongelli
This study uses molecular dynamics simulations to reveal a pseudo-active state in the A2A receptor, providing insights into its activation mechanism and signaling pathways.
DOI 10.1016/j.chempr.2024.08.004