Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells
L. Mordechay, A. Edri, U. Hadad, A. Porgador, M. Schvartzman, G. Le Saux
This paper shows that NK cells modulate their cytotoxic activity in response to surface stiffness, with a bell-shaped response peak at ~few hundreds of kPa, and links this to DAP10 clustering and a catch-bond model.
bioRxiv · Mar 2, 2020Immunology