Author

L. Strych

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

T. Dolezal· 3 shared A. Bajgar· 2 shared E. McMullen· 2 shared L. Chodakova· 2 shared P. Nedbalova· 2 shared A. Krebs· 1 shared G. Krejcova· 1 shared H. Zemanova· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

T. Dolezal

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3 papers

Recent·Most cited

JAK/STAT mediated insulin resistance in muscles is essential for effective immune response

E. McMullen, L. Strych, L. Chodakova, A. Krebs, T. Dolezal

This study shows that JAK/STAT signaling in muscles causes insulin resistance, redirecting nutrients to immune cells and improving survival during parasitoid infection in Drosophila.

bioRxiv · Oct 4, 2023Immunology

Metabolism of glucose and trehalose by cyclic pentose phosphate pathway is essential for effective immune response in Drosophila

M. Kazek, L. Chodakova, K. Lehr, L. Strych, P. Nedbalova, E. McMullen, A. Bajgar, P. Simek, M. Moos, T. Dolezal

bioRxiv · Aug 17, 2023 · PreprintImmunology

Macrophage-derived insulin/IGF antagonist ImpL2 regulates systemic metabolism for mounting an effective acute immune response in Drosophila

G. Krejcova, A. Bajgar, P. Nedbalova, J. Kovarova, N. Kamps-Hughes, H. Zemanova, L. Strych, T. Dolezal

This study shows that Drosophila macrophages release ImpL2, an insulin/IGF antagonist, to regulate systemic metabolism during acute immune responses, but this becomes maladaptive in chronic infections.

bioRxiv · Sep 24, 2020 · PreprintImmunology