NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion
L. Tille, D. Cropp, G. Bodley, M. Andreatta, M. Charmoy, I. Crespo-Casajus, S. Nassiri, J. Lourenco, M. M. Leblond, C. Lopez-Rodriguez, D. E. Speiser, S. J. Carmona, W. Held, G. Verdeil
This study identifies NFAT5 as a key driver of CD8 T cell exhaustion in the tumor microenvironment, showing its role in reducing tumor control and its absence improving it.
bioRxiv · Mar 15, 2022Immunology