ImmunologybioRxiv
NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion
L. Tille, D. Cropp, G. Bodley…·G. Verdeil
This study identifies NFAT5 as a key driver of CD8 T cell exhaustion in the tumor microenvironment, showing its role in reducing tumor control and its absence improving it.