Inhibitory CD200-receptor signaling is rewired by type I interferon
M. van der Vlist, M. I. Pascoal Ramos, L. L. van den Hoogen, S. Hiddingh, L. Timmerman, T. A. P. de Hond, E. D. Kaan, M. van der Kroef, R. J. Lebbink, F. M. A. Peters, W. Khoury-Hanold, R. Fritsch-Stork, T. Radstake, L. Meyaard
This study shows that type I interferon alters CD200R signaling by promoting RasGAP cleavage, converting CD200R from an inhibitor to a potentiator of IFNG mRNA production in SLE patients.
bioRxiv · Feb 6, 2020Immunology