A spatialised agent-based model of NOTCH signalling pathway in Endothelial Cells predicts emergent heterogeneity due to continual dynamic phenotypic adjustments.
F. Chesnais, T. J. Sego, E. Engstler, M. Battilocchi, D. Danovi, J. A. Glazier, L. Veschini
The paper uses a spatialised agent-based model to show NOTCH signalling pathway dynamics in endothelial cells can generate spatial heterogeneity through oscillations and phenotypic adjustments.
bioRxiv · Aug 6, 2022 · PreprintCell Biology