J. A. Glazier

The paper uses a spatialised agent-based model to show NOTCH signalling pathway dynamics in endothelial cells can generate spatial heterogeneity through oscillations and phenotypic adjustments.

The paper shows that Cadherin 8 and YAP1 drive cyst initiation and expansion, respectively, in 3D kidney cultures, with AMOTL1 inhibiting expansion.

This paper uses computational modeling to show that mechanical fluctuations in nutrient supply can accelerate tumor evolution by favoring low-adhesion cells.

This paper develops a method to convert non-spatial ODE models into spatial, agent-based models for multicellular systems, demonstrating applications in viral infection and showing how spatial models can reveal hidden biophysical mechanisms.

The paper introduces a modular simulation platform to model viral infection and immune response in epithelial tissue, showing that early low-dose antiviral treatment is more effective than late high-dose treatment.

This paper introduces a coupled simulation toolkit combining Geant4 and CompuCell3D to model radiation effects on tissue, enabling simulation of tumor response to radiation therapy.