Granzyme-targeting quenched activity-based probes for assessing tumor response to immunotherapy
Muhammad Kazim, Arghya Ganguly, Sebastian M. Malespini, Lai Thang, Nimit L. Patel, Caleb Kim, Kalyani Thakur, Joseph D. Kalen, Claudia Calcagno, Simone Difilippantonio, Euna Yoo
This paper develops a chemical probe to detect granzyme B activity in tumors, enabling noninvasive assessment of immunotherapy response.
Journal of the American Chemical Society · Oct 8, 2025Peer-reviewedMolecular Biology