Michelle A. Baird

This study shows that cholesterol metabolism remodeling in melanoma progression alters nuclear membrane mechanics, increasing tension and vulnerability to rupture during cellular confinement.

This study shows that increased LBR cholesterol synthase activity in metastatic melanoma leads to nuclear envelope fragility by accumulating cholesterol, promoting NE rupture during cell migration.

This study identifies key cellular programs and pathways driving metastatic organotropism in small cell lung cancer using preclinical models and multiomic profiling.