Programmable and Switchable RNA Scaffolds for Synthetic Condensate Engineering in Mammalian Cells
Zhaolin Xue, Oyeshik Mukherjee, Lan Mi, Yizhan Guo, Ru Zheng, Chang Yuan, Mingxu You
This paper develops programmable RNA scaffolds that form synthetic condensates in mammalian cells, showing that double-stranded RNA stems drive assembly and introducing an allosteric switch for reversible control.
bioRxiv · Feb 15, 2026 · PreprintBioengineering