Subtyping active-site inhibitor binding mode to Abl kinase using super-resolution nanopore tweezers.
Nguyen Ly, Yu-Hsiang Wang, Joshua C. Foster, David DeCoeur, Lan Nguyen, Bryant Wu, Olgica Milenković, Min Chen
This paper introduces a nanopore tweezers platform to subtype Abl kinase inhibitors by resolving ionic current signatures, achieving high classification accuracy without structural determination.
bioRxiv · Aug 29, 2026 · PreprintBiophysics