Larry D. Mesner

Targeted proteomics informed by long-read RNA-sequencing reveals protein isoform expression associated with bone mineral density

This study uses genetics-guided targeted mass spectrometry to detect protein isoforms associated with bone mineral density, confirming their expression in clinical samples.

Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

The paper uses single-cell transcriptomics in mice to identify cell type-specific networks and prioritize genes associated with human bone mineral density GWAS findings.

Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition

The paper identifies target genes and regulatory networks for bone mineral density GWAS loci using STING-seq, linking noncoding variants to gene function in osteoblasts.

Long read proteogenomics to connect disease-associated sQTLs to the protein isoform effectors of disease

This paper connects disease-associated splicing QTLs to protein isoform effects using long-read RNA-seq and GWAS data in osteoblasts.

Evaluation of a scalable approach to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells

The paper evaluates a scalable approach using scRNA-seq to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells from mouse bone marrow-derived stromal cells.

Transcriptome-wide Association Study and eQTL colocalization identify potentially causal genes responsible for bone mineral density GWAS associations

The paper identifies 512 potentially causal genes for bone mineral density using TWAS and eQTL colocalization, with PPP6R3 validated in mice.

Systems genetics analyses in Diversity Outbred mice inform human bone mineral density GWAS and identify Qsox1 as a novel determinant of bone strength

The paper uses Diversity Outbred mice to analyze bone traits and identify novel genes associated with bone strength, informing human GWAS findings.

Identification of known and novel long non-coding RNAs potentially responsible for the effects of BMD GWAS loci

The paper identifies 58 long non-coding RNAs potentially responsible for BMD GWAS associations by combining allelic imbalance, TWAS, and eQTL colocalization analyses.

Genetic Analysis of Osteoblast Activity Identifies Zbtb40 as a Regulator of Osteoblast Activity and Bone Mass

The paper identifies Zbtb40 as a regulator of osteoblast activity and bone mass through genetic analysis in mice, showing reduced BMD and mineralization upon Zbtb40 knockdown.

Mouse Genome-Wide Association and Systems Genetics Identifies Lhfp as a Regulator of Bone Mass

This study identifies Lhfp as a regulator of bone mass through GWAS and systems genetics in mice, showing its role in osteoblast differentiation and increased BMD.