Author

Laurel Ball

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 5 Research Focus:variant calling· 5 Assay:whole-genome sequencing· 5 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Xiaoxu YangiD· 6 shared Joseph G. GleesoniD· 5 shared Martin W. BreussiD· 5 shared Alexej S. AbyzoviD· 4 shared Christopher A. WalshiD· 4 shared Danny AntakiiD· 4 shared Renee D. GeorgeiD· 4 shared Taejeong BaeiD· 4 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersGenomics

Xiaoxu YangORCID

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6 papers

Recent·Most cited

Comprehensive multiomic profiling of somatic mutations in malformations of cortical development

Changuk Chung, Xiaoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil Mittal, Catharina Donkels, H. Westley Phillips, Zhen Li, Ashley P.L. Marsh, Martin W. Breuss, Laurel Ball, Camila Araújo Bernardino Garcia, Renee D. George, Jing Gu, Mingchu Xu, , Eduardo Maury

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

Nature Genetics · Jan 12, 2023Peer-reviewedGenetics

DeepMosaic: Control-independent mosaic single nucleotide variant detection using deep convolutional neural networks

Xiaoxu Yang, Xin Xu, Martin W. Breuss, Danny Antaki, Laurel Ball, Changuk Chung, Jiawei Shen, Chen Li, Renee D. George, Yifan Wang, Taejeong Bae, Yuhe Cheng, Alexej S. Abyzov, Liping Wei, Ludmil B. Alexandrov, , Sarah B. Emery

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

Nature Biotechnology · Jan 2, 2023Peer-reviewedGenomics

Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development

Martin W. Breuss, Xiaoxu Yang, Johannes C. M. Schlachetzki, Danny Antaki, Addison J. Lana, Xin Xu, Changuk Chung, Guoliang Chai, Valentina Stanley, Qiong Song, Traci Fang Newmeyer, An Nguyen, Sydney O’Brien, Marten A. Hoeksema, Beibei Cao, , Xiaowei Zhu

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

Nature · Apr 20, 2022Peer-reviewedGenomics

Temporal stability of human sperm mosaic mutations results in life-long threat of transmission to offspring

Xiaoxu Yang, Martin W. Breuss, Xin Xu, Danny Antaki, Kiely N. James, Valentina Stanley, Laurel Ball, Renee D. George, Sara A. Wirth, Beibei Cao, An Nguyen, Jennifer McEvoy‐Venneri, Guoliang Chai, Shareef Nahas, Lucitia Van Der Kraan, , Joseph G. Gleeson

The paper analyzes sperm mosaic mutations in healthy males, finding that many are stable over time and pose a lifelong transmission risk to offspring.

Cell · Aug 12, 2021Peer-reviewedGenomics

Comprehensive identification of somatic nucleotide variants in human brain tissue

Brain Somatic Mosaicism Network, Yifan Wang, Taejeong Bae, Jeremy Thorpe, Maxwell A. Sherman, Attila Jones, Sean Cho, Kenneth Daily, Yanmei Dou, Javier Ganz, Alon Galor, Irene Lobón, Reenal Pattni, Chaggai Rosenbluh, Simone Tomasi, , Alexej S. Abyzov

This study identifies somatic SNVs in non-cancerous human brain tissues and establishes best practices for detecting low-frequency variants.

Genome biology · Mar 29, 2021Peer-reviewedGenomics

Quantification of autism recurrence risk by direct assessment of paternal sperm mosaicism

Martin W. Breuss, Danny Antaki, Renee D. George, Morgan L. Kleiber, Kiely N. James, Laurel Ball, Oanh Hong, Ileena Mitra, Xiaoxu Yang, Sara A. Wirth, Jing Gu, Camila Araújo Bernardino Garcia, Madhusudan Gujral, William M. Brandler, Damir Musaev, , Joseph G. Gleeson

The paper quantifies autism recurrence risk by detecting paternal sperm mosaicism through single molecule genotyping and whole genome sequencing.

Nature Medicine · Dec 23, 2019Peer-reviewedGenetics