Author

Mingchu Xu

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:variant calling· 3 Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Assay:whole-exome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Abeer M. ShaabaniD· 1 shared Ahmed A. AhmediD· 1 shared Ahmed Al-RawiiD· 1 shared Alastair Mark ThompsoniD· 1 shared Alejandra G. SerranoiD· 1 shared Alexandra W. van den Belt‐DuseboutiD· 1 shared Alexej S. AbyzoviD· 1 shared Alice Lee· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Abeer M. ShaabanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Comparison of imaging-based single-cell resolution spatial transcriptomics profiling platforms using formalin-fixed, paraffin-embedded tumor samples

Nejla Ozirmak Lermi, Max Molina Ayala, Sharia D. Hernandez, Wei Lü, Khaja B. Khan, Alejandra G. Serrano, Idania Carolina Lubo Julio, Leticia Hamana, Katarzyna J. Tomczak, Sean Barnes, Jinzhuang Dou, Qingnan Liang, RTI Team, Ahmed Al-Rawi, Claudio A. Arrechedera, , Luisa M. Solis Soto

This study compares imaging-based spatial transcriptomics platforms using FFPE tumor samples, finding differences in performance and highlighting factors affecting data quality.

Nature Communications · Sep 26, 2025Peer-reviewedBioinformatics

Comprehensive multiomic profiling of somatic mutations in malformations of cortical development

Changuk Chung, Xiaoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil Mittal, Catharina Donkels, H. Westley Phillips, Zhen Li, Ashley P.L. Marsh, Martin W. Breuss, Laurel Ball, Camila Araújo Bernardino Garcia, Renee D. George, Jing Gu, Mingchu Xu, , Eduardo Maury

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

Nature Genetics · Jan 12, 2023Peer-reviewedGenetics

Genomic profiling defines variable clonal relatedness between invasive breast cancer and primary ductal carcinoma in situ

Esther H. Lips, Tapsi Kumar, Anargyros Megalios, Lindy L. Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A. Ahmed, Mingchu Xu, Alexandra W. van den Belt‐Dusebout, Wim Brugman, , Elinor J. Sawyer

The paper uses genomic profiling to show that some invasive breast cancers are clonally unrelated to their preceding DCIS, suggesting DCIS may act as both a precursor and independent risk factor.

Nature Genetics · Jun 1, 2022Peer-reviewedGenetic & Genomic Medicine

GRIPT: A novel case-control analysis method for Mendelian disease gene discovery

Jun Wang, Li Zhao, Xia Wang, Yong Chen, Mingchu Xu, Zachry T. Soens, Zhongqi Ge, Peter Ronghan Wang, Fei Wang, Rui Chen

GRIPT is a case-control analysis method for NGS data that improves disease gene discovery, particularly in highly heterogeneous Mendelian diseases.

Genome biology · Nov 26, 2018Peer-reviewedGenomics