Author

Laurell F. Kessler

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 4 Research Focus:cell type annotation· 3 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Approach:deep learning· 1

Frequent Co-Authors

Mike HeilemanniD· 6 shared Ashwin BalakrishnaniD· 4 shared Ellen Kazumi OkudaiD· 2 shared Marina S. DietziD· 2 shared Marius GloggeriD· 2 shared Michaela Müller-McNicolliD· 2 shared Yunqing LiiD· 2 shared Alexander HeckeliD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersBiophysics

Mike HeilemannORCID

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6 papers

Recent·Most cited

Wash-Free Multi-Target Super-Resolution Microscopy with Photocaged DNA Labels

Nina Kaltenschnee, Marina S. Dietz, Laurell F. Kessler, Yunqing Li, Janik Kaufmann, Alexander Heckel, Mike Heilemann

This paper introduces a wash-free method for multi-target super-resolution microscopy using photocaged DNA labels, demonstrating improved imaging accuracy without sample manipulation.

Angewandte Chemie International Edition · Mar 13, 2026Peer-reviewedBiophysics

Quantitative STED microscopy with DNA-fluorophore labels

Laurell F. Kessler, Yunqing Li, Ashwin Balakrishnan, Mike Heilemann

This paper introduces a method for quantitative STED microscopy using DNA-fluorophore labels to enable molecule counting in biological samples.

bioRxiv · Dec 7, 2025 · PreprintBiophysics

Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body

Enya S. Berrevoets, Laurell F. Kessler, Ashwin Balakrishnan, Ellen Kazumi Okuda, Michaela Müller-McNicoll, Bernd Rieger, Sjoerd Stallinga, Mike Heilemann

The paper uses smart 3D super-resolution microscopy to study the RNA scaffold structure in paraspeckles, revealing new insights into their 3D organization and growth.

Nature Communications · Nov 27, 2025Peer-reviewedBiophysics

Rapid depletion and super-resolution microscopy reveal an unexpected role of the nuclear-speckle protein SRSF5 in paraspeckle assembly and dynamics during cellular stress

Ellen Kazumi Okuda, Laurell F. Kessler, Benjamin Arnold, Ricarda J. Riegger, María Clara Hernández Cañás, Ewelina Żebrowska, Cem Bakisoglu, Mara Rudigier, Christine Krost, Helder Yudi Nagasse, Jan Keiten‐Schmitz, Stefan P Müller, David Staněk, Dorothee Dormann, Kathi Zarnack, , Michaela Müller-McNicoll

This study shows SRSF5 is critical for paraspeckle assembly and dynamics, with stress-induced changes and compensatory effects on TDP-43 and NEAT1.

Nucleic Acids Research · Jul 14, 2025Peer-reviewedCell Biology

Fast and long-term super-resolution imaging of ER nano-structural dynamics in living cells using a neural network

Johanna V. Rahm, Ashwin Balakrishnan, Maren H. Wehrheim, Alexandra Kaminer, Marius Glogger, Laurell F. Kessler, Matthias Kaschube, Hans‐Dieter Barth, Mike Heilemann

This paper enables long-term super-resolution imaging of ER dynamics in living cells using low irradiation and neural network-based image restoration.

Small Science · Nov 8, 2024Peer-reviewedBiophysics

Self-quenched fluorophore-DNA labels for super-resolution fluorescence microscopy

Laurell F. Kessler, Ashwin Balakrishnan, Tanja Menche, Dongni Wang, Yunqing Li, Maximilian Mantel, Marius Glogger, Marina S. Dietz, Mike Heilemann

The paper introduces self-quenched fluorophore-DNA labels to reduce background signal in super-resolution microscopy, improving imaging performance in STED and SMLM.

The Journal of Physical Chemistry B · Jul 2, 2024Peer-reviewedBiophysics