Author

Lea Costes

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:Hi-C· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Kerstin BystrickyiD· 2 shared Manoel ManghiiD· 2 shared Martin Rey‐MilletiD· 2 shared Alexia PigeotiD· 1 shared Amal Zine El AabidineiD· 1 shared Antonio TrulloiD· 1 shared Cyril EsnaultiD· 1 shared Erwan Le FlochiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

Kerstin BystrickyORCID

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2 papers

Recent·Most cited

Cell Cycle-Dependent Chromatin Motion: A Role for DNA Content Doubling Over Cohesion

Martin Rey‐Millet, Lea Costes, Erwan Le Floch, Habib Ayoub, Quentin Saccomani, Manoel Manghi, Kerstin Bystricky

The paper uses Hi-D to track chromatin motion in live human cells and finds that DNA content doubling, not cohesin, reduces chromatin mobility during the cell cycle.

Nucleic Acids Research · Sep 22, 2026Peer-reviewedBiophysics

Extracellular matrix stiffness modulates nuclear lamina organisation and sets nuclear conditions for PRC2 repression.

Alexia Pigeot, Martin Rey‐Millet, Amal Zine El Aabidine, Antonio Trullo, Lea Costes, Manoel Manghi, Kerstin Bystricky, Jean‐Christophe Andrau, Cyril Esnault

The paper shows ECM stiffness alters nuclear lamina composition and PRC2-mediated gene repression through changes in chromatin structure and motion.

bioRxiv · Sep 7, 2025 · PreprintGenomics