Systematic comparison of dCas9-based DNA methylation epimodifiers over time indicates efficient on-target and widespread off-target effects
Majid Pahlevan Kakhki, Fatemeh Rangani, Ewoud Ewing, Chiara Starvaggi Cucuzza, Galina Yurevna Zheleznyakova, Maria Kalomoiri, Lea Kenny, Anika Raghavan, Chandana Rao Prakash, Gabe van den Hoeven, T. S., Ruxandra Covacu, Ioanna Andreou, Maria Needhamsen, Lara Kular, M Jagodic
This study compares dCas9-based DNA methylation epimodifiers over time, showing efficient on-target effects but widespread off-target methylation and transcriptional changes.
Genome biology · Jan 31, 2026Peer-reviewedMolecular Biology