Author

M Jagodic

Karolinska University Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Maria NeedhamseniD· 4 shared Fredrik PiehliD· 3 shared Lara KulariD· 3 shared Majid Pahlevan KakhkiiD· 3 shared Chandana Rao Prakash· 2 shared Chiara SoriniiD· 2 shared Chiara Starvaggi CucuzzaiD· 2 shared Galina Yurevna ZheleznyakovaiD· 2 shared

Activity by Year

2019-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Maria NeedhamsenORCID

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Author profile →

5 papers

Recent·Most cited

Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis

Yanan Han, Galina Yurevna Zheleznyakova, Chiara Sorini, Majid Pahlevan Kakhki, Nicolas Ruffin, Heng Liang, Nils Hallen, Chandana Rao Prakash, Viveca Beckers, Elena Ivanova, Mohsen Khademi, Mikael C. I. Karlsson, Fredrik Piehl, Tomas P Olsson, Gavin Kelsey, , M Jagodic

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

bioRxiv · Feb 27, 2026 · PreprintImmunology

Systematic comparison of dCas9-based DNA methylation epimodifiers over time indicates efficient on-target and widespread off-target effects

Majid Pahlevan Kakhki, Fatemeh Rangani, Ewoud Ewing, Chiara Starvaggi Cucuzza, Galina Yurevna Zheleznyakova, Maria Kalomoiri, Lea Kenny, Anika Raghavan, Chandana Rao Prakash, Gabe van den Hoeven, T. S., Ruxandra Covacu, Ioanna Andreou, Maria Needhamsen, Lara Kular, M Jagodic

This study compares dCas9-based DNA methylation epimodifiers over time, showing efficient on-target effects but widespread off-target methylation and transcriptional changes.

Genome biology · Jan 31, 2026Peer-reviewedMolecular Biology

Whole-genome profiling of native 5-hydroxymethylation in human neurons with long-read sequencing

Dennis Klose, Mohammad Hossein Sepehri, Remi-Andre Olsen, Ha T.H. Vu, Jason Ernst, Lara Kular, Maria Needhamsen, M Jagodic

The paper uses long-read sequencing to profile native 5hmC and 5mC in human neurons, showing 5hmC enrichment in transcribed regions and enhancers.

bioRxiv · Jan 12, 2026 · PreprintNeuroscience

Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple Sclerosis

Olivia G. Thomas, Urszula Rykaczewska, Marina Galesic, Rianne T. M. van der Burgt, Nils Hallen, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Rique, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, Andras Levente Szonder, Chiara Sorini, , Tomas P Olsson

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

Cell · Jan 1, 2026Peer-reviewedImmunology✦ In-depth digest

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

Nikolaos A. Patsopoulos, Sergio E. Baranzini, Adam Santaniello, Parisa Shooshtari, Chris J. Cotsapas, Garrett T. Wong, Ashley Harris Beecham, Tojo James, Joseph M. Replogle, Ioannis S. Vlachos, Cristin Aubin, Tune H. Pers, Aaron Brandes, Charles C. White, Brendan T Keenan, , John W. Thorpe

The paper reports a detailed genetic and genomic map of multiple sclerosis, identifying susceptibility genes in peripheral immune cells and brain-resident microglia.

Science · Sep 26, 2019Peer-reviewedGenetics