Sex, not estrous cycle stage, drives differences in the microglial transcriptome in the 5xFAD mouse model of amyloidosis
L. Calcines-Rodríguez, Nikita Noyes-Martel, Jennifer D. Becker, S. K. Nguyen, Mark Osabutey, Lee Trojanczyk, Ania Katarzyna Majewska, M. Kerry O’Banion
The paper investigates sex differences in microglial transcriptomes in 5xFAD mice, finding that sex, not estrous cycle stage, drives these differences with female microglia showing distinct gene expression patterns.
Journal of Neuroinflammation · Dec 27, 2025Peer-reviewedNeuroscience