Lei Yu

JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

This paper investigates JAK-STAT pathway heterogeneity in breast cancer and finds that high JSP activity correlates with improved immunotherapy response, particularly in triple-negative breast cancer.

DeMoP: A Language-Model-Guided Mixture-of-Experts Framework for Cancer Prognosis

DeMoP uses a language-model-guided mixture-of-experts framework to improve cancer prognosis by integrating clinical and molecular data across cohorts.

Phasing of the 'Wonderful' Pomegranate Genome Using Haploid DNA Extracted from Pollen Grains

The paper presents a haplotype-resolved genome assembly of the pomegranate cultivar 'Wonderful' using DNA from haploid pollen grains and long-read sequencing technologies.

3D reconstruction of spatial transcriptomics with spatial pattern enhanced graph convolutional neural network

This paper introduces Spa3D, a method that reconstructs 3D spatial structures from 2D spatial transcriptomics data, improving spatial domain identification, cell-cell communication analysis, and developmental trajectory modeling.

A single-molecule nanopore sequencing platform

This paper introduces an improved nanopore sequencing platform called CycloneSEQ, demonstrating long-duration sequencing and high yield with applications in genomics.

Stable changing fluid shear stress promotes osteogenesis

This study examines how stable versus unstable fluid shear stress affects osteogenesis in bone marrow-derived mesenchymal stem cells, finding that stable stress promotes osteogenesis through the OPG-RANKL-RANK pathway.

Brain xQTL Map: Integrating The Genetic Architecture Of The Human Brain Transcriptome And Epigenome

The paper identifies xQTLs in the human brain integrating RNA, DNA methylation, and histone acetylation data from 411 individuals, revealing 18 new CNS disease susceptibility loci.