Author

Lemuel Chang

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

David A. BakeriD· 3 shared Alex KangiD· 2 shared An‐Qi CheniD· 2 shared Asim K. BeraiD· 2 shared Brian CoventryiD· 2 shared Hannah NguyeniD· 2 shared Kejia WuiD· 2 shared Xinting LiiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

David A. BakerORCID

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Author profile →

3 papers

Recent·Most cited

Design of readers for pathological PTM proteoforms in Alzheimer's disease

Kejia Wu, Tiana Schantz, Lemuel Chang, Prarthna Chabria, Elaina Bashaw, Thejesh Reddy Kalatturu, Doo Yeon Kim, An‐Qi Chen, Nathaniel Corley, Asim K. Bera, Alex Kang, Hannah Nguyen, Johnny Mendoza, Xinting Li, Magnus S. Bauer, , David A. Baker

The paper designs and validates protein readers that specifically detect disease-related modifications in Tau and Abeta in Alzheimer's disease models and human samples.

bioRxiv · Oct 21, 2026 · PreprintBioengineering

Computational design of metalloproteases

An‐Qi Chen, Kejia Wu, Hojae Choi, Preetham Venkatesh, Samuel J. Pellock, Nikita Hanikel, Hojeong Shin, Declan Evans, Kieran Didi, Lars L Schaaf, Cristina Díaz‐Perlas, Brian Coventry, Donghyo Kim, Seth M. Woodbury, Pengfei Ji, , David A. Baker

This paper designs de novo metalloproteases using RoseTTAFold Diffusion 2, achieving high activity and specificity for cleaving various substrates.

Nature · Oct 14, 2026Peer-reviewedBiochemistry

Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity

Riya Keshri, Marc Expòsit, Mohamad H. Abedi, Derrick R. Hicks, Zachary Foreman, Ashish Phal, Yen Chian Lim, Philip Barrett, Catherine M Sniezek, Jinlong Lin, Thomas Schlichthaerle, Alexander Robinson, Damien Detraux, Tung Chan Ching, Keija Wu, , Hannele Ruohola‐Baker

This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.

bioRxiv · Oct 12, 2025 · PreprintBiochemistry