A human immune system mouse model for preclinical evaluation of therapies in pemphigoid disease
Leonie Voss, Katharina Maier, Stella Wagner, Ann‐Kathrin Schneider, Mareile Schlotfeldt, Leon Altmann, Emir Ucgan, Lukas Honninger, Matthias Peipp, Falk Nimmerjahn, Katja Bieber, Anja Lux
This study develops a human immune system mouse model for EBA, demonstrating that PDK1 inhibition reduces skin inflammation and immune cell activation.
bioRxiv · Jan 15, 2026 · PreprintImmunology