Author

Leon Deng

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metagenomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bin WuiD· 2 shared Pan P. LiiD· 2 shared Anna X. LuoiD· 1 shared Chengqian Zhou· 1 shared Christopher A. RossiD· 1 shared Fatemeh Jahanbakhsh· 1 shared Hans B. LiuiD· 1 shared Junnan LiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Bin WuORCID

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Author profile →

2 papers

Recent·Most cited

A bipolar disorder-associated ultra-rare AKAP11 protein-truncating variant attenuates stimulus-dependent PKA activation and induces anxiety- and depression-related behaviors in mice

Anna X. Luo, Leon Deng, Yannan Li, Xiaodi Zhang, Junnan Li, Xiaolei Zhu, Xiaobo Mao, Yijing Su, Bin Wu, Christopher A. Ross, Pan P. Li

This study introduces an ultra-rare AKAP11 protein-truncating variant in mice, showing it causes anxiety- and depression-like behaviors and disrupts PKA signaling.

bioRxiv · Sep 28, 2026 · PreprintNeuroscience

Bidirectional transcription at the PPP2R2B gene locus in spinocerebellar ataxia type 12

Chengqian Zhou, Hans B. Liu, Fatemeh Jahanbakhsh, Leon Deng, Bin Wu, Mingyao Ying, Russell L. Margolis, Pan P. Li

This study identifies bidirectional transcription at the PPP2R2B gene locus in SCA12 and shows that expanded antisense transcripts are toxic and contribute to disease pathogenesis.

Movement Disorders · Sep 21, 2023Peer-reviewedNeuroscience