Author

Leshan Yang

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Yifan DaiiD· 3 shared Wen Hao YuiD· 2 shared Anton Z. NiiD· 1 shared Joonho LeeiD· 1 shared Matthew R. KingiD· 1 shared Michael W Chen· 1 shared Michael W. Chen· 1 shared Mina FaragiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

Yifan DaiORCID

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Author profile →

3 papers

Recent·Most cited

Condenzymes: Biomolecular condensates with inherent catalytic activities

Michael W. Chen, Xiao Guo, Mina Farag, Naixin Qian, Xiaowei Song, Anton Z. Ni, Vicky Liu, Yu Xia, Yuefeng Ma, Leshan Yang, Wen Yu, Matthew R. King, Joonho Lee, Richard N. Zare, Wei Min, , Yifan Dai

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

Molecular Cell · Jul 24, 2026Peer-reviewedBiophysics

Asymmetry in hydrophobicity induces electric potential in non-charged protein condensates

Leshan Yang, Wen Hao Yu, Xiangze Zeng, Yifan Dai

This study shows that hydrophobic asymmetry in non-charged protein condensates creates electric potential gradients, enabling potential-dependent chemistry.

bioRxiv · Oct 15, 2025 · PreprintBiophysics

Phase transition pathways encode distinct physicochemical properties of biomolecular condensates

Xiaokang Ren, Leshan Yang, Michael W Chen, Yifan Dai

This study identifies pathway-dependent molecular interactions that define distinct physicochemical properties of biomolecular condensates formed by the same IDP.

bioRxiv · Mar 26, 2025 · PreprintBiophysics