Donor-derived CD8+CD122+ Tregs generated in mixed donor chimeric NOD mice suppress autoreactive T cells
Shiva Pathak, Cameron S. Bader, Bettina Panagiota Iliopoulou, Shobha Regmi, Pin-I Chen, Biki Gupta, Xiangni Wu, Blake Mosher, Alexandra Wells, Levon Witherspoon, Kayla Jenkins, William Harper, Emily Soohoo, Abigail Twoy, Rizwan Ahmed, , Everett H. Meyer
This study identifies donor-derived CD8+CD122+ Tregs in mixed chimeric NOD mice that suppress autoreactive T cells and may offer a new therapeutic strategy for autoimmune diabetes.
Journal of Clinical Investigation · Oct 27, 2026Peer-reviewedImmunology