Author

Lifeng Fu

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:DNA methylation· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Chang Xu· 2 shared Hanyi Liao· 2 shared Huijun Zhang· 2 shared Jianxun QiiD· 2 shared Qiyue Wang· 2 shared Weiwei LiiD· 2 shared Yang LiiD· 2 shared Meng YangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Chang Xu

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2 papers

Recent·Most cited

Structural Insights into Single-Stranded DNA Recognition and Modified Substrate Tolerance in an Engineered Terminal Deoxynucleotidyl Transferase

Yang Li, Hanyi Liao, Qiyue Wang, Weiwei Li, Chang Xu, Jianxun Qi, Huijun Zhang, Lifeng Fu, Meng Yang

This paper presents the crystal structure of an engineered TdT variant and shows how mutations alter substrate specificity to accommodate bulky DNA terminators.

bioRxiv · Dec 26, 2025 · PreprintBiochemistry

Structural Mechanism of Specific Nucleobase Recognition by a Monoclonal Antibody in CoolMPSTM Sequencing

Yang Li, Qiyue Wang, Hanyi Liao, Weiwei Li, Chang Xu, Jianxun Qi, Huijun Zhang, Lifeng Fu, Meng Yang

This paper reports the crystal structures of an antibody used in CoolMPS sequencing, revealing the structural basis for its high specificity in recognizing modified nucleotides.

bioRxiv · Dec 23, 2025 · PreprintBiochemistry