Author

Chang Xu

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Hanyi Liao· 2 shared Huijun Zhang· 2 shared Jianxun QiiD· 2 shared Lifeng Fu· 2 shared Qiyue Wang· 2 shared Weiwei LiiD· 2 shared Yang LiiD· 2 shared Aarav Badani· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Hanyi Liao

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Author profile →

3 papers

Recent·Most cited

Platelets regulate glioblastoma growth and immunity via sex-dependent PAR4 - Estrogen receptor beta signaling

Anthony R. Sloan, George Bukenya, Gavin P. Tannish, Daniel J. Silver, Anu Aggarwal, Juyeun Lee, Daniel Rosoff, Tyler J. Alban, Ivan Juric, Shikha Parsai, Vargab Baruah, Tyler Bodovetz, Donovan Whitfield, Liza Tack, Tanvi Navadgi, , Justin Durla Lathia

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

Cancer Cell · Oct 1, 2026Peer-reviewedCancer Biology

Structural Insights into Single-Stranded DNA Recognition and Modified Substrate Tolerance in an Engineered Terminal Deoxynucleotidyl Transferase

Yang Li, Hanyi Liao, Qiyue Wang, Weiwei Li, Chang Xu, Jianxun Qi, Huijun Zhang, Lifeng Fu, Meng Yang

This paper presents the crystal structure of an engineered TdT variant and shows how mutations alter substrate specificity to accommodate bulky DNA terminators.

bioRxiv · Dec 26, 2025 · PreprintBiochemistry

Structural Mechanism of Specific Nucleobase Recognition by a Monoclonal Antibody in CoolMPSTM Sequencing

Yang Li, Qiyue Wang, Hanyi Liao, Weiwei Li, Chang Xu, Jianxun Qi, Huijun Zhang, Lifeng Fu, Meng Yang

This paper reports the crystal structures of an antibody used in CoolMPS sequencing, revealing the structural basis for its high specificity in recognizing modified nucleotides.

bioRxiv · Dec 23, 2025 · PreprintBiochemistry