Behavioral dysfunction but not wasting in cancer cachexia is driven by altered tryptophan metabolism
Damon Fard, Edisa Pirani, Maria Gomez-Jenkins, Sereno L. Lopez-Darwin, Maria Ibrahim, Lilia Schell, Charlotte Larkin, Clara Gorgui, Clara Berdasco, Zhixian Hu, Trishna Das, Jesse Powers, Tracy Gautsch Anthony, Joshua D. Rabinowitz, Benjamin J. Raphael, , Eileen White
The paper identifies altered tryptophan metabolism in cancer cachexia, showing serotonin depletion and kynurenine accumulation, which drive behavioral dysfunction but not wasting.
bioRxiv · Oct 9, 2026 · PreprintCancer Biology