Lin Fan

Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule-RNA binding events in native cells

The paper identifies RNA targets of splice modulating small molecules using photoaffinity labeling and validates binding sites with cellular SHAPE-MaP.

A spontaneous mutation in ADIPOR1 causes retinal degeneration in mice

A mutation in AdipoR1 causes retinal degeneration in a subset of Cfh-/- mice, suggesting a genetic interaction between Cfh and AdipoR1.

APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium Cells

This study investigates how APOE variants affect lipid trafficking in RPE cells, finding that APOE knockout and APOE2-expressing cells show lipid transport deficits, while APOE4-expressing cells upregulate APOE in response to lipid challenges.

A comprehensive fitness landscape model reveals the evolutionary history and future evolvability of eukaryotic cis-regulatory DNA sequences

The paper constructs a deep transformer model to predict gene expression from cis-regulatory DNA sequences in yeast, revealing evolutionary constraints and evolvability patterns.

Comparative analysis highlights variable genome content of wheat rusts and divergence of the mating loci.

The paper compares the genomes of three wheat rust pathogens to identify gene content variation and divergence in mating loci, highlighting differences in genome size, heterozygosity, and effector expression.