Author

Lin Jiang

Guangdong Academy of Medical Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetics· 4 Bioinformatics· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Miaoxin LiiD· 3 shared Mulin Jun LiiD· 2 shared Alexander S. LeonardiD· 1 shared Alfonso P. FarruggioiD· 1 shared Angel Adrian CataldiiD· 1 shared Bingjie LiiD· 1 shared Bingjin LiniD· 1 shared Bingxing AniD· 1 shared

Activity by Year

2016-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBioinformatics

Miaoxin LiORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Global expression profile of Enterohemorrhagic Escherichia coli O157:H7 in phagosome of murine macrophages

Nahuel Agustín Riviere, Lin Jiang, Xiuju Wu, Pablo Farace, Lu Guo, Libia Yael Smith, W. Silva, Angel Adrian Cataldi, Ke Xing, Jinlong Bei, Mariano Larzábal

This study profiles the global gene expression of EHEC O157:H7 in murine macrophage phagosomes under stress conditions, revealing survival strategies like SOS response activation and upregulation of stx2a.

Brazilian Journal of Microbiology · Sep 8, 2026Peer-reviewedMicrobiology

Placental invasion mismatch underlines pregnancy disorders and cancers

Xin Li, Ruixue Chen, Yangyi Zhang, Yuchen Sun, Wenqiang Du, Dan Yu, Ye Lu, Xiang Fang, Xupeng Bi, Yijun Yang, J F Zhu, Kailin Sun, Jiaming Liang, Lin Jiang, Yunqiu He, , Guojie Zhang

The paper identifies conserved regulatory programs in placental invasion across mammals and links their dysregulation to pregnancy disorders and cancers.

bioRxiv · Jul 11, 2026 · PreprintEvolutionary Biology

The enhanced multi-tissue atlas of regulatory effects in cattle

Houcheng Li, Huicong Zhang, Di Zhu, Pengju Zhao, Zhenyu Wei, Jiaqi Lu, Mian Gong, Qi Zhang, Weijie Zheng, Xia Liu, Dailu Guan, Jinyan Teng, Qing Lin, Yongjie Tang, Yahui Gao, , Lingzhao Fang

The paper presents CattleGTEx, a resource characterizing regulatory effects in cattle, resolving GWAS signals and providing insights into adaptive evolution and selection.

bioRxiv · Mar 21, 2026 · PreprintGenetics

S-SELeCT: A Human-Evolved Serine Integrase System for Efficient Large-Cargo Genome Integration

Alfonso P. Farruggio, Lin Jiang, Karen Duong, Cynthia Nguyen, Razan Kaddoura, Ruby Tsai

The paper introduces S-SELeCT, a human-evolved serine integrase system for efficient large-cargo genome integration, achieving up to 32% integration frequency in stable lines.

Nucleic Acids Research · Mar 19, 2026Peer-reviewedGenetics

A global overview of single-cell type selectivity and pleiotropy in complex diseases and traits

Chao Xue, Lin Jiang, Qihan Long, Ying Chen, Xiangyi Li, Miaoxin Li

The paper constructs a cell-type-phenotype association landscape using scRNA-seq and GWAS data to identify cell-type selectivity and pleiotropy in complex diseases.

bioRxiv · Nov 18, 2020 · PreprintGenetics

Systematic comparative analysis of Mendelian randomization methods for inferring causal genes of complex phenotypes and the application to psychiatric diseases

Lin Jiang, Guorong Yi, Xiangyi Li, Chao Xue, Mulin Jun Li, Hailiang Huang, Miaoxin Li

This study compares multiple Mendelian randomization methods for causal gene inference in complex phenotypes, identifies two robust methods, and applies them to psychiatric diseases to discover known and novel causal genes.

bioRxiv · Nov 9, 2020 · PreprintBioinformatics

WITER: A powerful method for the estimation of cancer-driver genes using a weighted iterative regression accurately modelling background mutation rate

Lin Jiang, Jingjing Zheng, Johnny Sheung Him Kwan, Sheng Dai, Cong Li, Mulin Jun Li, Bolan Yu, Ka Fai To, Pak Chung Sham, Yonghong Zhu, Miaoxin Li

WITER improves cancer-driver gene detection by accurately modeling background mutations, identifying 178 driver genes across 26 cancers with high validation rates.

bioRxiv · Feb 10, 2019 · PreprintBioinformatics

Whole-genome sequencing of an advanced case of small-cell gallbladder neuroendocrine carcinoma

Maolan Li, Fatao Liu, Yijian Zhang, Xiangsong Wu, Wenguang Wu, Xu-An Wang, Shuai Zhao, Shibo Liu, Haibin Liang, Fei Zhang, Yuan Gao, Shanshan Xiang, Huaifeng Li, Wei Lu, Hao Weng, , Yingbin Liu

This study performs whole-genome sequencing on an advanced case of small-cell gallbladder neuroendocrine carcinoma to identify genetic alterations and potential biomarkers.

bioRxiv · May 9, 2016 · PreprintGenetics