Therapeutic Potential of Hypoxia-Preconditioned hiPSC-Epicardial Cell-Derived Exosomes in Mice with Myocardial Infarction
Zhixuan Qiu, Yun Jiang, Pengfei Zhang, Hao Li, Yaoxian Yu, Yanshan Gong, ling gao
This study compares the cardioprotective effects of normoxic and hypoxic exosomes from hiPSC-derived epicardial cells in MI mice, finding that hypoxic exosomes provide superior protection through miR-214-3p-mediated mechanisms.
bioRxiv · Apr 22, 2026 · PreprintCell Biology