IL13 critically contributes to the antitumor activity of polyfunctional CD4+ T cells driven by constitutively active Stat5
Ogacheko D. Okoko, Mercy Kehinde-Ige, Xin Wang, Yan Ye, Aarav Bhasin, Lirong Pei, Caitlin Brandle, Md Y. Gazi, Zhi-chun Ding, Rafal Pacholczyk, Huidong Shi, Gang Zhou
This study identifies IL13 as a critical cytokine for the antitumor activity of polyfunctional CD4+ T cells modified with constitutively active Stat5, showing its role in enhancing immune responses and tumor control.
bioRxiv · Nov 10, 2026 · PreprintImmunology