Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase
Long Yang, Liwei Yi, Bang Gong, Lili Chen, Miao Li, Xiangcheng Zhu, Yanwen Duan, Yong Huang
The paper identifies and characterizes the chm biosynthetic gene cluster responsible for chalkophomycin production in Streptomyces sp. CB00271 and proposes a biosynthesis model based on sequence analysis and structural modeling.
bioRxiv · Mar 14, 2024Biochemistry