Structural determinants of IGHV1-69 public antibodies conferring resilience to SARS-CoV-2 antigenic escape
Chuanying Niu, Xiaohan Huang, Qihong Yan, Banghui Liu, Xijie Gao, Yidong Song, J. Y. Wang, Longyu Wang, Zimu Li, Huiran Zheng, Ping He, Xiaodong Huang, Hang Yuan, Binqian Zou, Yuedong Yang, , Xiaoli Xiong
This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.
bioRxiv · Mar 23, 2026 · PreprintImmunology