J. Y. Wang

This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.

This study shows that structural flexibility in computationally designed protein assemblies leads to multiple architectures, expanding their functional possibilities.

This study shows that overexpressing Zaxinone Synthase in rice increases zaxinone levels, enhances growth, and improves phosphate uptake, leading to higher grain yield.

This study shows that abscisic acid (ABA) inhibits Striga seed germination but is released by germinated seeds as a rhizospheric signal to enhance competitive advantage and host infestation.

This study identifies intrinsic AT2 progenitor dysfunction and p53 pathway dysregulation as novel mechanisms driving pulmonary fibrosis in Hermansky-Pudlak syndrome.

This study identifies the role of OsMAX1-1400 in rice by showing its specific contribution to canonical strigolactone biosynthesis and its impact on plant architecture and rhizospheric interactions.

The paper profiles apocarotenoids and CCD gene expression in rice during AM symbiosis and phosphate conditions, identifying novel markers.

The paper identifies a CRISPR trimmer-integrase that processes DNA for integration in the absence of Cas4, using cryo-EM structures to show its mechanism.

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

This study identifies OsZAS2 as a zaxinone-forming enzyme in rice that regulates growth, development, and arbuscular mycorrhizal symbiosis.

This paper identifies AtD27-like1 as a cis/cis-{beta}-carotene isomerase that contributes to strigolactone biosynthesis and negatively affects ABA levels in Arabidopsis.

This study shows canonical strigolactones in rice are not responsible for shoot branching inhibition but act as rhizospheric signals to influence Striga germination and mycorrhizal colonization.

This study evaluates a nanoparticle vaccine displaying EBV gH/gL, showing it protects humanized mice against lethal EBV challenge, while monomeric gH/gL does not.

The paper identifies a master autoantigen-ome linking alternative splicing, female predilection, and COVID-19 to autoimmune diseases through analysis of 751 autoantigens across six human cell types.

This study identifies 140 autoantigens from Jurkat T-cells, showing 75% are autoantibody targets and 89% are altered in SARS-CoV-2 infection, linking them to autoimmune and cancer-related pathways.

This study identifies 362 autoantigens from HS-Sultan B-lymphoblasts, showing 87% are affected by SARS-CoV-2 infection, offering insights into COVID-19-induced autoimmunity.

This study identifies 348 autoantigens from human A549 lung cells, revealing viral and host factors involved in autoimmunity during SARS-CoV-2 infection.

The study identifies an autoantigenome from human lung HFL1 cells using dermatan sulfate affinity, linking it to neurological and autoimmune complications of COVID-19.

This study identifies dermatan sulfate (DS) as a master regulator of IgH in pre-B cells by interacting with pre-BCR components, GTF2I, and ER proteins, influencing autoreactive B cell development and autoimmunity.

This study identifies the lncRNA PLANE as a regulator of alternative splicing that promotes cancer progression by repressing NCOR2-202 splicing, leading to poor patient outcomes.

The paper determines the cryo-EM structure of a Cas6-RT-Cas1-Cas2 complex and shows bidirectional and unidirectional crosstalk between its active sites.

This study shows IL-8 promotes cellular plasticity and therapeutic resistance in glioblastoma by altering epigenetic marks and enhancing cancer initiating cell properties.

This study uses CRISPR/Cas9 to disrupt CCD7 in rice, altering strigolactone biosynthesis and resulting in increased tillering and a dwarf phenotype.

The paper shows that nuclear Abl drives miR-34c secretion via extracellular vesicles, which induce ROS and DNA damage in non-irradiated cells, causing radiation bystander effects.