Serum modulates the aggregation - toxicity landscape of the staphylococcal toxin PSMα3
Laura Bonnecaze, Alysson Duchalet, Louis Moine, Anthony Vial, Marité Cárdenas, Cesar Augusto Martín, Michaël Molinari, Sophie Marsaudon, Marion Mathelié‐Guinlet
This study shows serum lipoproteins inhibit PSMα3 aggregation and cytotoxicity by preventing oligomer and fibril formation, revealing a general mechanism of amyloid peptide toxicity.
bioRxiv · Feb 22, 2026 · PreprintBiophysics