Author

Lu Han

Fudan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioengineering· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Andreas HeinziD· 1 shared Antoine GrigisiD· 1 shared Arun L.W. BokdeiD· 1 shared B. X. Li· 1 shared Baochao FaniD· 1 shared Barbara Jacquelyn SahakianiD· 1 shared Boshui Yuan· 1 shared Chao XieiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Andreas HeinzORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Segmented poly(A) tails with microRNA target sites confer tissue-specific regulation for mRNA therapeutics

Rui Qi, Hua Chen, Hui Bao, Ying Sun, Ruiwen Xu, Lu Han, Yingmei Xu, Juan Li, Na Li, Qiang Li, Tingting Zhang, Kai Lv, Yijie Dong, Shan Cen, Weiguo Zhang

This study engineers segmented poly(A) tails with microRNA target sites to enable tissue-specific regulation of mRNA-LNPs, showing position-dependent expression control in vitro and in vivo.

Molecular Therapy — Nucleic Acids · Sep 8, 2026Peer-reviewedBioengineering

Coronavirus envelope protein drives iron sensing disorder by hijacking the TAp73-FDXR axis

Mingjun Zhu, Leyu Hu, Xingwei Fu, Boshui Yuan, Guiwen Guan, Lu Han, Zesheng Rong, Ru Tian, Gen Li, Muzi Du, Yan Ma, Ning Xu, Haixin Liu, Haolun Tian, Xinhuan Yin, , Dewen Tong

This study identifies how the coronavirus envelope protein disrupts the TAp73-FDXR axis to cause iron overload, leading to iron deficiency perception and tissue damage, and presents a therapeutic molecule to counteract this effect.

bioRxiv · Mar 25, 2026 · PreprintMicrobiology

Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function

Lu Han, Edmund T. Rolls, Hanjia Liu, Dan Joseph Stein, Barbara Jacquelyn Sahakian, Rebecca Elliott, Tianye Jia, Chao Xie, Shitong Xiang, Nan Wang, Tobias Banaschewski, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, , Qiang Luo

The paper identifies a genetic-dependent brain signature of resilience linked to childhood abuse and depression risk in girls, showing its predictive value for emotional disorders in adolescence and early adulthood.

bioRxiv · Sep 16, 2024 · PreprintNeuroscience