Gen Li

Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.

Spikes meet Spins: Quantum-Native Neural Decoding for Ultra_Low-Latency Brain-Computer Interfaces

This paper demonstrates a quantum computing approach for neural decoding with high accuracy and ultra-low latency using a photonic Ising machine.

Coronavirus envelope protein drives iron sensing disorder by hijacking the TAp73-FDXR axis

This study identifies how the coronavirus envelope protein disrupts the TAp73-FDXR axis to cause iron overload, leading to iron deficiency perception and tissue damage, and presents a therapeutic molecule to counteract this effect.

LUMI-lab: a Foundation Model-Driven Autonomous Platform Enabling Discovery of New Ionizable Lipid Designs for mRNA Delivery

LUMI-lab autonomously designs ionizable lipids for mRNA delivery, identifying brominated tails and achieving 20.3% gene editing efficacy in mice.

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

The paper develops S-PrediXcan to compute gene expression associations from GWAS summary data and applies it to 44 GTEx tissues and 100+ phenotypes, finding tissue-specific effects and colocalized associations.

Local genetic effects on gene expression across 44 human tissues

This study identifies cis-eQTLs across 44 human tissues using GTEx data, showing 88% of genes have cis-eQTLs and demonstrating their utility in understanding complex trait etiology.

A novel quantile regression approach for eQTL discovery

This paper introduces a quantile regression method to identify eQTLs associated with gene expression distribution, finding new eQTLs with tissue-specific effects and enrichment in GWAS SNPs.