Lucas Lizardos

Single Molecule Diffusion Studies Reveal Rapid Translations Across Target Membrane Surfaces for both p40Phox PX domain and Class III PI3K VPS34 Complex 1, the Autophagy Lipid Kinase

This paper uses single molecule tracking to study how p40Phox PX domain and VPS34 Complex 1 move across lipid bilayers, revealing electrostatic hopping and docking mechanisms.

COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3KγRBD Frequently Generate Affinity Increases

The paper investigates how mutations at the H-Ras:PI3KγRBD interface affect binding affinity, finding that some mutations increase affinity while others decrease it, suggesting intermediate native affinity.